大麻素在风湿性疾病治疗中的应用

随着大麻在世界范围内的医学应用越来越广泛，对该药效果与风险的了解是必要的。

与风湿性疾病相关的疼痛，是各种国家医用大麻的适应症。



到目前为止，初步临床试验已经探索大麻对类风湿关节炎、骨关节炎和纤维肌痛的影响；初步证据还发现大麻素系统与其他风湿性疾病，包括系统性硬化和幼年特发性关节炎之间的关联。

大麻的潜在药效可能是由于它对免疫系统的影响，对各种免疫细胞（包括T细胞、B细胞和巨噬细胞）发挥免疫调节作用。然而，现有的证据还不足以支持大麻素治疗风湿性疾病的建议。

参考文献：

NatureReviews Rheumatology. 2018 June. Cannabinoids for thetreatment of rheumatic diseases. Abstract: As medical use ofcannabis is increasingly legalized worldwide, a better understanding of themedical and hazardous effects of this drug is imperative. The pain associatedwith rheumatic diseases is considered a prevalent indication for medicinalcannabis in various countries. Thus far, preliminary clinical trials have exploredthe effects of cannabis on rheumatoid arthritis, osteoarthritis andfibromyalgia; preliminary evidence has also found an association between thecannabinoid system and other rheumatic conditions, including systemic sclerosisand juvenile idiopathic arthritis. The potential medicinal effects of cannabiscould be attributable to its influence on the immune system, as it exerts animmunomodulatory effect on various immune cells, including T cells, B cells andmacrophages. However, the available evidence is not yet sufficient to supportthe recommendation of cannabinoid treatment for rheumatic diseases.